Remodelling of a homeobox gene cluster by multiple independent gene reunions in Drosophila
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چکیده
منابع مشابه
Rhox: A New Homeobox Gene Cluster
Homeobox genes encode transcription factors notable for their ability to regulate embryogenesis. Here, we report the discovery of a cluster of 12 related homeobox genes on the X chromosome expressed in male and female reproductive tissues in adult mice. These reproductive homeobox on the X chromosome (Rhox) genes are expressed in a cell type-specific manner; several are hormonally regulated, an...
متن کاملNk6, a novel Drosophila homeobox gene regulated by vnd
Nk(x)-type homeobox genes are an evolutionarily conserved family that regulate diverse developmental processes. Here we describe a novel Drosophila gene, Nk6, which encodes an Nk-type transcription factor most homologous to vertebrate Nkx6.1 and Nkx6.2. The homeodomains and NK decapeptide domains of all three proteins are highly conserved. Nk6 is expressed in the embryonic brain, ventral nerve ...
متن کاملThe Drosophila homeobox gene optix is capable of inducing ectopic eyes by an eyeless-independent mechanism.
optix is a new member of the Six/so gene family from Drosophila that contains both a six domain and a homeodomain. Because of its high amino acid sequence similarity with the mouse Six3 gene, optix is considered to be the orthologous gene from Drosophila rather than sine oculis, as previously believed. optix expression was detected in the eye, wing and haltere imaginal discs. Ectopic expression...
متن کاملChannel Gene Cluster of Drosophila
To elucidate the mechanisms regulating expression of para, which encodes the major class of sodium channels in the Drosophila nervous system, we have tried to locate upstream &acting regulatory elements by mapping the transcriptional start site and analyzing the region immediately upstream of para in region 14D of the polytene chromosomes. From these studies, we have discovered that the region ...
متن کاملSupplemental Data Rhox: A New Homeobox Gene Cluster
Cell Type Specificity of Rhox Gene Expression in Testes To identify the cell types in the testis that express the Rhox genes, we purified testicular cell fractions enriched for Sertoli and interstitial (e.g., Leydig) cells. Although it is not possible to generate entirely pure populations of these cell types, our fractions were substantially enriched, based on the relative levels of Sertoli and...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2015
ISSN: 2041-1723
DOI: 10.1038/ncomms7509